Department of Comparative Medicine

The Comparative Pathology Program (CPP) in the Department of Comparative Medicine (DCM) at the University of Washington School of Medicine integrates the pathology of laboratory animal species with basic science and systems biology. Which results in the improved development and translation of animal models to human diseases. The CPP faculty are veterinarians with specialty training in molecular disease pathogenesis and comparative pathobiology of model organisms. The CPP has two specialized programs including Comparative Neuropathology (CNP-P) and Comparative Pathology of Aging (CPA-P). CPP faculty engage in training of DCM residents, graduate students, research, and technical staff in comparative pathology and use of animal models in translational research.

The Gnotobiotic Animal Core (GNAC) at the University of Washington (UW) is a core facility started in 2014 and managed by the Department of Comparative Medicine.  Located in the UW Health Sciences Center, the GNAC is open to investigators with research needs to maintain mice free of any microorganisms (germ-free), or with a known population of microorganisms (gnotobiotic).

The Department of Comparative Medicine (DCM) -managed BSL3/ABSL3 facility is a state-of-the-art high containment research facility designed for both in vitro and in vivo research requiring biosafety level 3 (BSL3) containment, including work with select agents.

The In Vivo Services (IVS) Core in the Department of Comparative Medicine provides rodent colony management at the UW. IVS staff will oversee the maintenance, breeding, weaning, identification, and record keeping of your mouse and rat colonies to free up the limited and valuable time of your laboratory personnel. In addition, the IVS Core offers an array of technical services performing procedures such as sample collection, sample administration, and testing of drug compounds in rodents. All services through the IVS Core are charged on an hourly tech time rate.

The Transgenic Resources Program (TRP) is a core facility that creates transgenic and gene-targeted mice using pronuclear microinjection, targeted ES cell microinjection, and CRISPR/Cas9 gene editing.  The TRP also offers mouse rederivation services to create specific pathogen free mice or to rederive cryopreserved mouse lines.  Additionally, embryo and sperm cryopreservation services are available to provide long-term storage of valuable mouse strains or stocks.

The University of Washington Mouse CRISPR Core (UWMCC) is a cost center administered through the Department of Comparative Medicine at the University of Washington (UW), Seattle, WA. The UWMCC is a full-service facility offering rapid, precise and economical generation of novel transgenic mouse models using CRISPR/Cas9 gene editing technology. Our standard service includes consultation, design, testing, prep, mouse embryo microinjection, and genotyping all at a competitive price point. The UWMCC is a joint collaboration utilizing 15 years of gene-editing experience by the UW Transgenic Resources Program, the UW Institute for Stem Cell and Regenerative Medicine, and the Vector and Transgenic Mouse Core of the UW Diabetes Research Center.

The University of Washington Preclinical Research Organization (UW PRO) at the University of Washington (UW) provides support for both internal (UW) and external (outside of UW) collaborators, researchers, and scientists.

Managed by the Department of Comparative Medicine, the UW PRO provides in-life services including the Transgenic Resources Program (TRP), In Vivo Services (IVS), the Gnotobiotic Animal Core (GNAC), the BSL3/ABSL3 facility, and the Patient Derived Xenograft (PDX) Core, the Histology and Imaging Core (HIC) and pathology consultation via the Comparative Pathology Program (CPP).